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Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams
In this report, we describe the construction of chiral α,β-unsaturated δ-lactams, a widely used pharmacophore, in high yields and excellent enantioselectivities using an oxidative relay Heck arylation reaction. This strategy also allows facile access to 7-substituted α,β-unsaturated ε-lactam product...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5993423/ https://ncbi.nlm.nih.gov/pubmed/29746119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02752 |
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