De novo biosynthesis of sterols and fatty acids in the Trypanosoma brucei procyclic form: Carbon source preferences and metabolic flux redistributions

De novo biosynthesis of lipids is essential for Trypanosoma brucei, a protist responsible for the sleeping sickness. Here, we demonstrate that the ketogenic carbon sources, threonine, acetate and glucose, are precursors for both fatty acid and sterol synthesis, while leucine only contributes to ster...

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Vydáno v:PLoS Pathog
Hlavní autoři: Millerioux, Yoann, Mazet, Muriel, Bouyssou, Guillaume, Allmann, Stefan, Kiema, Tiila-Riikka, Bertiaux, Eloïse, Fouillen, Laetitia, Thapa, Chandan, Biran, Marc, Plazolles, Nicolas, Dittrich-Domergue, Franziska, Crouzols, Aline, Wierenga, Rik K., Rotureau, Brice, Moreau, Patrick, Bringaud, Frédéric
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993337/
https://ncbi.nlm.nih.gov/pubmed/29813135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1007116
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