De Novo Synthesis of Elastin by Exogenous Delivery of Synthetic Modified mRNA into Skin and Elastin-Deficient Cells

Elastin is one of the most important and abundant extracellular matrix (ECM) proteins that provide elasticity and resilience to tissues and organs, including vascular walls, ligaments, skin, and lung. Besides hereditary diseases, such as Williams-Beuren syndrome (WBS), which results in reduced elast...

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Publicat a:Mol Ther Nucleic Acids
Autors principals: Lescan, Mario, Perl, Regine Mariette, Golombek, Sonia, Pilz, Martin, Hann, Ludmilla, Yasmin, Mahua, Behring, Andreas, Keller, Timea, Nolte, Andrea, Gruhn, Franziska, Kochba, Efrat, Levin, Yotam, Schlensak, Christian, Wendel, Hans Peter, Avci-Adali, Meltem
Format: Artigo
Idioma:Inglês
Publicat: American Society of Gene & Cell Therapy 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992474/
https://ncbi.nlm.nih.gov/pubmed/29858082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2018.03.013
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