Lysosomal Targeting Enhancement by Conjugation of Glycopeptides Containing Mannose-6-phosphate Glycans Derived from Glyco-engineered Yeast

Many therapeutic enzymes for lysosomal storage diseases require a high content of mannose-6-phosphate (M6P) glycan, which is important for cellular uptake and lysosomal targeting. We constructed glyco-engineered yeast harboring a high content of mannosylphosphorylated glycans, which can be converted...

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Publicat a:Sci Rep
Autors principals: Kang, Ji-Yeon, Shin, Keun Koo, Kim, Ha Hyung, Min, Jeong-Ki, Ji, Eun Sun, Kim, Jin Young, Kwon, Ohsuk, Oh, Doo-Byoung
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992200/
https://ncbi.nlm.nih.gov/pubmed/29880804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-26913-4
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