Mouse medulloblastoma driven by CRISPR activation of cellular Myc

MYC-driven Group 3 (G3) medulloblastoma (MB) is the most aggressive of four molecular subgroups classified by transcriptome, genomic landscape and clinical outcomes. Mouse models that recapitulate human G3 MB all rely on retroviral vector-induced Myc expression driven by viral regulatory elements (R...

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Udgivet i:Sci Rep
Main Authors: Vo, BaoHan T., Kwon, Jin Ah, Li, Chunliang, Finkelstein, David, Xu, Beisi, Orr, Brent A., Sherr, Charles J., Roussel, Martine F.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992137/
https://ncbi.nlm.nih.gov/pubmed/29880921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24956-1
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