Short Telomeres Induce p53 and Autophagy and Modulate Age-Associated Changes in Cardiac Progenitor Cell Fate

Aging severely limits myocardial repair and regeneration. Delineating the impact of age-associated factors such as short telomeres is critical to enhance the regenerative potential of cardiac progenitor cells (CPCs). We hypothesized that short telomeres activate p53 and induce autophagy to elicit th...

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Pubblicato in:Stem Cells
Autori principali: Matsumoto, Collin, Jiang, Yan, Emathinger, Jacqueline, Quijada, Pearl, Nguyen, Nathalie, De La Torre, Andrea, Moshref, Maryam, Nguyen, Jonathan, Levinson, Aimee B., Shin, Minyoung, Sussman, Mark A., Hariharan, Nirmala
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5992026/
https://ncbi.nlm.nih.gov/pubmed/29441645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2793
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