Pim1 maintains telomere length in mouse cardiomyocytes by inhibiting TGFβ signalling

AIMS: Telomere attrition in cardiomyocytes is associated with decreased contractility, cellular senescence, and up-regulation of proapoptotic transcription factors. Pim1 is a cardioprotective kinase that antagonizes the aging phenotype of cardiomyocytes and delays cellular senescence by maintaining...

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Publicat a:Cardiovasc Res
Autors principals: Ebeid, David E, Khalafalla, Farid G, Broughton, Kathleen M, Monsanto, Megan M, Esquer, Carolina Y, Sacchi, Veronica, Hariharan, Nirmala, Korski, Kelli I, Moshref, Maryam, Emathinger, Jacqueline, Cottage, Christopher T, Quijada, Pearl J, Nguyen, Jonathan H, Alvarez, Roberto, Völkers, Mirko, Konstandin, Mathias H, Wang, Bingyan J, Firouzi, Fareheh, Navarrete, Julian M, Gude, Natalie A, Goumans, Marie-Jose, Sussman, Mark A
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797214/
https://ncbi.nlm.nih.gov/pubmed/32176281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvaa066
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