Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus

Through the action of two virus-encoded decapping enzymes (D9 and D10) that remove protective caps from mRNA 5′-termini, Vaccinia virus (VACV) accelerates mRNA decay and limits activation of host defenses. D9- or D10-deficient VACV are markedly attenuated in mice and fail to counter cellular double-...

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Bibliographic Details
Published in:Mol Ther Oncolytics
Main Authors: Burgess, Hannah M., Pourchet, Aldo, Hajdu, Cristina H., Chiriboga, Luis, Frey, Alan B., Mohr, Ian
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991893/
https://ncbi.nlm.nih.gov/pubmed/29888320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2018.01.001
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