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Targeting Poxvirus Decapping Enzymes and mRNA Decay to Generate an Effective Oncolytic Virus
Through the action of two virus-encoded decapping enzymes (D9 and D10) that remove protective caps from mRNA 5′-termini, Vaccinia virus (VACV) accelerates mRNA decay and limits activation of host defenses. D9- or D10-deficient VACV are markedly attenuated in mice and fail to counter cellular double-...
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| Publicado no: | Mol Ther Oncolytics |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Gene & Cell Therapy
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5991893/ https://ncbi.nlm.nih.gov/pubmed/29888320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2018.01.001 |
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