Lack of acquired resistance in HER2-positive breast cancer cells after long-term HER2 siRNA nanoparticle treatment

Intrinsic and acquired resistance to current HER2 targeted therapies remains a challenge in clinics. We have developed a therapeutic HER2 siRNA delivered using mesoporous silica nanoparticles modified with polymers and conjugated with HER2 targeting antibodies. Our previous studies have shown that o...

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Bibliographic Details
Published in:PLoS One
Main Authors: Gu, Shenda, Ngamcherdtrakul, Worapol, Reda, Moataz, Hu, Zhi, Gray, Joe W., Yantasee, Wassana
Format: Artigo
Language:Inglês
Published: Public Library of Science 2018
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991725/
https://ncbi.nlm.nih.gov/pubmed/29879129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0198141
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