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PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies

To quantify polygenic effects, i.e. undetected genetic effects, in large-scale association studies, we propose a generalized estimating equation (GEE) based estimation framework. We develop a marginal model for single-variant association test statistics of complex diseases that generalizes existing...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Biostatistics
मुख्य लेखकों: Hecker, Julian, Prokopenko, Dmitry, Lange, Christoph, Fier, Heide Loehlein
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2018
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5991211/
https://ncbi.nlm.nih.gov/pubmed/28968646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxx040
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