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PolyGEE: a generalized estimating equation approach to the efficient and robust estimation of polygenic effects in large-scale association studies
To quantify polygenic effects, i.e. undetected genetic effects, in large-scale association studies, we propose a generalized estimating equation (GEE) based estimation framework. We develop a marginal model for single-variant association test statistics of complex diseases that generalizes existing...
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| Publicado no: | Biostatistics |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5991211/ https://ncbi.nlm.nih.gov/pubmed/28968646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxx040 |
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