Utilizing the Jaccard index to reveal population stratification in sequencing data: a simulation study and an application to the 1000 Genomes Project

Motivation: Population stratification is one of the major sources of confounding in genetic association studies, potentially causing false-positive and false-negative results. Here, we present a novel approach for the identification of population substructure in high-density genotyping data/next gen...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Bioinformatics
Main Authors: Prokopenko, Dmitry, Hecker, Julian, Silverman, Edwin K., Pagano, Marcello, Nöthen, Markus M., Dina, Christian, Lange, Christoph, Fier, Heide Loehlein
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Original Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860507/
https://ncbi.nlm.nih.gov/pubmed/26722118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btv752
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