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Novobiocin enhances polymyxin activity by stimulating lipopolysaccharide transport

Gram-negative bacteria are challenging to kill with antibiotics due to their impenetrable outer membrane containing lipopolysaccharide (LPS). The polymyxins, including colistin, are the drugs of last resort for treating Gram-negative infections. These drugs bind LPS and disrupt the outer membrane; h...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Am Chem Soc
Main Authors: Mandler, Michael D., Baidin, Vadim, Lee, James, Pahil, Karanbir S., Owens, Tristan W., Kahne, Daniel
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5990483/
https://ncbi.nlm.nih.gov/pubmed/29746111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b02283
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