Combining Mutations That Inhibit Two Distinct Steps of the ATP Hydrolysis Cycle Restores Wild-Type Function in the Lipopolysaccharide Transporter and Shows that ATP Binding Triggers Transport

ATP-binding cassette (ABC) transporters constitute a large family of proteins present in all domains of life. They are powered by dynamic ATPases that harness energy from binding and hydrolyzing ATP through a cycle that involves the closing and reopening of their two ATP-binding domains. The LptB(2)...

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Detalhes bibliográficos
Publicado no:mBio
Main Authors: Simpson, Brent W., Pahil, Karanbir S., Owens, Tristan W., Lundstedt, Emily A., Davis, Rebecca M., Kahne, Daniel, Ruiz, Natividad
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6703430/
https://ncbi.nlm.nih.gov/pubmed/31431556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01931-19
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