The antibiotic novobiocin binds and activates the ATPase that powers lipopolysaccharide transport

Novobiocin is an orally active antibiotic that inhibits DNA gyrase by binding the ATP-binding site in the ATPase subunit. Although effective against Gram-positive pathogens, novobiocin has limited activity against Gram-negative organisms due to the presence of the lipopolysaccharide-containing outer...

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Publicado no:J Am Chem Soc
Main Authors: May, Janine M., Owens, Tristan W., Mandler, Michael D., Simpson, Brent W., Lazarus, Michael B., Sherman, David J., Davis, Rebecca M., Okuda, Suguru, Massefski, Walter, Ruiz, Natividad, Kahne, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5735422/
https://ncbi.nlm.nih.gov/pubmed/29135241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07736
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