Collagen type I induces EGFR‐TKI resistance in EGFR‐mutated cancer cells by mTOR activation through Akt‐independent pathway

Primary resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs) is a serious problem in lung adenocarcinoma patients harboring EGFR mutations. The aim of this study was to examine whether and how collagen type I (Col I), the most abundantly deposited matrix in tumor str...

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Bibliografiska uppgifter
I publikationen:Cancer Sci
Huvudupphovsmän: Yamazaki, Shota, Higuchi, Youichi, Ishibashi, Masayuki, Hashimoto, Hiroko, Yasunaga, Masahiro, Matsumura, Yasuhiro, Tsuchihara, Katsuya, Tsuboi, Masahiro, Goto, Koichi, Ochiai, Atsushi, Ishii, Genichiro
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2018
Ämnen:
Original Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989854/
https://ncbi.nlm.nih.gov/pubmed/29701925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13624
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