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Repetitive Aerosol Exposure Promotes Cavitary Tuberculosis and Enables Screening for Targeted Inhibitors of Extensive Lung Destruction

BACKGROUND: Cavitation is a serious consequence of tuberculosis. We tested the hypothesis that repetitive exposure to the same total bacterial burden of Mycobacterium tuberculosis drives greater lung destruction than a single exposure. We also tested whether inhibition of endogenous matrix metallopr...

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Bibliografski detalji
Izdano u:J Infect Dis
Glavni autori: Urbanowski, Michael E, Ihms, Elizabeth A, Bigelow, Kristina, Kübler, André, Elkington, Paul T, Bishai, William R
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5989619/
https://ncbi.nlm.nih.gov/pubmed/29554286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy127
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