Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology

Matrix metalloproteinases (MMPs) degrade extracellular matrix and are implicated in tuberculosis pathogenesis and cavitation. In particular, MMP-7 is induced by hypoxia and highly expressed around pulmonary cavities of Mycobacterium tuberculosis–infected C3HeB/FeJ mice. In this study, we evaluated w...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Ordonez, Alvaro A, Pokkali, Supriya, Sanchez-Bautista, Julian, Klunk, Mariah H, Urbanowski, Michael E, Kübler, André, Bishai, William R, Elkington, Paul T, Jain, Sanjay K
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6601699/
https://ncbi.nlm.nih.gov/pubmed/29920600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiy373
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