Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers

BACKGROUND: Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanc...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Cortes, Jorge, Tamura, Kenji, DeAngelo, Daniel J., de Bono, Johann, Lorente, David, Minden, Mark, Uy, Geoffrey L., Kantarjian, Hagop, Chen, Lisa S., Gandhi, Varsha, Godin, Robert, Keating, Karen, McEachern, Kristen, Vishwanathan, Karthick, Pease, Janet Elizabeth, Dean, Emma
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988656/
https://ncbi.nlm.nih.gov/pubmed/29765150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0082-1
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