Phase I studies of AZD1208, a proviral integration Moloney virus kinase inhibitor in solid and haematological cancers

BACKGROUND: Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanc...

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Veröffentlicht in:Br J Cancer
Hauptverfasser: Cortes, Jorge, Tamura, Kenji, DeAngelo, Daniel J., de Bono, Johann, Lorente, David, Minden, Mark, Uy, Geoffrey L., Kantarjian, Hagop, Chen, Lisa S., Gandhi, Varsha, Godin, Robert, Keating, Karen, McEachern, Kristen, Vishwanathan, Karthick, Pease, Janet Elizabeth, Dean, Emma
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988656/
https://ncbi.nlm.nih.gov/pubmed/29765150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0082-1
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