PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

Alveolar rhabdomyosarcoma is a pediatric soft-tissue sarcoma caused by PAX3/7-FOXO1 fusion oncogenes and is characterized by impaired skeletal muscle development. We developed human PAX3-FOXO1 -driven zebrafish models of tumorigenesis and found that PAX3-FOXO1 exhibits discrete cell lineage suscepti...

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Veröffentlicht in:eLife
Hauptverfasser: Kendall, Genevieve C, Watson, Sarah, Xu, Lin, LaVigne, Collette A, Murchison, Whitney, Rakheja, Dinesh, Skapek, Stephen X, Tirode, Franck, Delattre, Olivier, Amatruda, James F
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2018
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988421/
https://ncbi.nlm.nih.gov/pubmed/29869612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.33800
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