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Oligomerization of a molecular chaperone modulates its activity

Molecular chaperones alter the folding properties of cellular proteins via mechanisms that are not well understood. Here, we show that Trigger Factor (TF), an ATP-independent chaperone, exerts strikingly contrasting effects on the folding of non-native proteins as it transitions between a monomeric...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Saio, Tomohide, Kawagoe, Soichiro, Ishimori, Koichiro, Kalodimos, Charalampos G
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988418/
https://ncbi.nlm.nih.gov/pubmed/29714686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.35731
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