Optical Structural Analysis of Individual α‐Synuclein Oligomers

Small aggregates of misfolded proteins play a key role in neurodegenerative disorders. Such species have proved difficult to study due to the lack of suitable methods capable of resolving these heterogeneous aggregates, which are smaller than the optical diffraction limit. We demonstrate here an all...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Varela, Juan A., Rodrigues, Margarida, De, Suman, Flagmeier, Patrick, Gandhi, Sonia, Dobson, Christopher M., Klenerman, David, Lee, Steven F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5988047/
https://ncbi.nlm.nih.gov/pubmed/29342318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201710779
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