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Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia

Peripherally derived macrophages infiltrate the brain after bone marrow transplantation and during central nervous system (CNS) inflammation. It was initially suggested that these engrafting cells were newly derived microglia and that irradiation was essential for engraftment to occur. However, it r...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Cronk, James C., Filiano, Anthony J., Louveau, Antoine, Marin, Ioana, Marsh, Rachel, Ji, Emily, Goldman, Dylan H., Smirnov, Igor, Geraci, Nicholas, Acton, Scott, Overall, Christopher C., Kipnis, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987928/
https://ncbi.nlm.nih.gov/pubmed/29643186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20180247
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