Cholesterol negatively regulates IL-9–producing CD8(+) T cell differentiation and antitumor activity

CD8(+) T cells can be polarized into IL-9–secreting (Tc9) cells. We previously showed that adoptive therapy using tumor-specific Tc9 cells generated stronger antitumor responses in mouse melanoma than classical Tc1 cells. To understand why Tc9 cells exert stronger antitumor responses, we used gene p...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Ma, Xingzhe, Bi, Enguang, Huang, Chunjian, Lu, Yong, Xue, Gang, Guo, Xing, Wang, Aibo, Yang, Maojie, Qian, Jianfei, Dong, Chen, Yi, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987919/
https://ncbi.nlm.nih.gov/pubmed/29743292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171576
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