Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer

In colorectal cancer, signaling pathways driving tumor progression are promising targets for systemic therapy. Besides WNT and MAPK signaling, activation of NOTCH signaling is found in most tumors. Here, we demonstrate that high NOTCH activity marks a distinct colon cancer cell subpopulation with lo...

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Veröffentlicht in:J Exp Med
Hauptverfasser: Schmidt, Eva Marina, Lamprecht, Sebastian, Blaj, Cristina, Schaaf, Christian, Krebs, Stefan, Blum, Helmut, Hermeking, Heiko, Jung, Andreas, Kirchner, Thomas, Horst, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: Rockefeller University Press 2018
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987917/
https://ncbi.nlm.nih.gov/pubmed/29769248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171455
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