Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer

In colorectal cancer, signaling pathways driving tumor progression are promising targets for systemic therapy. Besides WNT and MAPK signaling, activation of NOTCH signaling is found in most tumors. Here, we demonstrate that high NOTCH activity marks a distinct colon cancer cell subpopulation with lo...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Schmidt, Eva Marina, Lamprecht, Sebastian, Blaj, Cristina, Schaaf, Christian, Krebs, Stefan, Blum, Helmut, Hermeking, Heiko, Jung, Andreas, Kirchner, Thomas, Horst, David
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987917/
https://ncbi.nlm.nih.gov/pubmed/29769248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171455
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