Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Protects Against Neuronal Apoptosis via Activation of Akt/MDM2/p53 Signaling Pathway in a Rat Model of Intracerebral Hemorrhage

Neuronal apoptosis plays key roles in secondary brain injury caused by intracerebral hemorrhage (ICH). This study first reported the role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in alleviating secondary brain injury through anti-apoptosis in rat model of ICH. The recombinant hu...

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Udgivet i:Front Mol Neurosci
Main Authors: Xu, Weilin, Gao, Liansheng, Li, Tao, Zheng, Jingwei, Shao, Anwen, Zhang, Jianmin
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987019/
https://ncbi.nlm.nih.gov/pubmed/29896089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2018.00176
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