Multi-omics profiling reveals a distinctive epigenome signature for high-risk acute promyelocytic leukemia

Epigenomic alterations have been associated with both pathogenesis and progression of cancer. Here, we analyzed the epigenome of two high-risk APL (hrAPL) patients and compared it to non-high-risk APL cases. Despite the lack of common genetic signatures, we found that human hrAPL blasts from patient...

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Foilsithe in:Oncotarget
Main Authors: Singh, Abhishek A., Petraglia, Francesca, Nebbioso, Angela, Yi, Guoqiang, Conte, Mariarosaria, Valente, Sergio, Mandoli, Amit, Scisciola, Lucia, Lindeboom, Rik, Kerstens, Hinri, Janssen-Megens, Eva M., Pourfarzad, Farzin, Habibi, Ehsan, Berentsen, Kim, Kim, Bowon, Logie, Colin, Heath, Simon, Wierenga, Albertus T.J., Clarke, Laura, Flicek, Paul, Jansen, Joop H., Kuijpers, Taco, Yaspo, Marie Laure, Valle, Veronique Della, Bernard, Olivier, Gut, Ivo, Vellenga, Edo, Stunnenberg, Hendrik G., Mai, Antonello, Altucci, Lucia, Martens, Joost H.A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2018
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986653/
https://ncbi.nlm.nih.gov/pubmed/29876014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25429
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