The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer

OBJECTIVE: Homologous recombination (HR)-proficient ovarian tumors have poorer clinical outcomes and show resistance to poly ADP ribose polymerase inhibitors (PARPi). A subset of HR-proficient ovarian tumors show amplification in bromodomain and extra-terminal (BET) genes such as BRD4. We aimed to t...

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Bibliografiske detaljer
Udgivet i:Gynecol Oncol
Main Authors: Wilson, Andrew J., Stubbs, Matthew, Liu, Phillip, Ruggeri, Bruce, Khabele, Dineo
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986599/
https://ncbi.nlm.nih.gov/pubmed/29567272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2018.03.049
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