Suberoylanilide Hydroxamic Acid (SAHA) enhances olaparib activity by targeting homologous recombination DNA repair in ovarian cancer

OBJECTIVES: Approximately 50% of serous epithelial ovarian cancers (EOC) contain molecular defects in homologous recombination (HR) DNA repair pathways. Poly(ADP-ribose) polymerase inhibitors (PARPi) have efficacy in HR-deficient, but not HR-proficient, EOC tumors as a single agent. Our goal was to...

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Udgivet i:Gynecol Oncol
Main Authors: Konstantinopoulos, Panagiotis A., Wilson, Andrew J., Saskowski, Jeanette, Wass, Erica, Khabele, Dineo
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347923/
https://ncbi.nlm.nih.gov/pubmed/24631446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2014.03.007
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