Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib

OBJECTIVE: Homologous recombination (HR) proficient ovarian cancers, including CCNE1 (cyclin E)-amplified tumors, are resistant to poly (ADP-ribose) polymerase inhibitors (PARPi). Histone deacetylase inhibitors (HDACi) are effective in overcoming tumor resistance to DNA damaging drugs. Our goal was...

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Publicado en:Gynecol Oncol
Autores principales: Wilson, Andrew J., Sarfo-Kantanka, Kofi, Barrack, Toby, Steck, Alexandra, Saskowski, Jeanette, Crispens, Marta A., Khabele, Dineo
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5031537/
https://ncbi.nlm.nih.gov/pubmed/27444036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2016.07.088
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