The antibiotic cyclomarin blocks arginine-phosphate–induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis

Mycobacterium tuberculosis can remain dormant in the host, an ability that explains the failure of many current tuberculosis treatments. Recently, the natural products cyclomarin, ecumicin, and lassomycin have been shown to efficiently kill Mycobacterium tuberculosis persisters. Their target is the...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Weinhäupl, Katharina, Brennich, Martha, Kazmaier, Uli, Lelievre, Joel, Ballell, Lluis, Goldberg, Alfred, Schanda, Paul, Fraga, Hugo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986217/
https://ncbi.nlm.nih.gov/pubmed/29632076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002251
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