The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo

Drug-resistant tuberculosis (TB) has lent urgency to finding new drug leads with novel modes of action. A high-throughput screening campaign of >65,000 actinomycete extracts for inhibition of Mycobacterium tuberculosis viability identified ecumicin, a macrocyclic tridecapeptide that exerts potent...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Gao, Wei, Kim, Jin-Yong, Anderson, Jeffrey R., Akopian, Tatos, Hong, Seungpyo, Jin, Ying-Yu, Kandror, Olga, Kim, Jong-Woo, Lee, In-Ae, Lee, Sun-Young, McAlpine, James B., Mulugeta, Surafel, Sunoqrot, Suhair, Wang, Yuehong, Yang, Seung-Hwan, Yoon, Tae-Mi, Goldberg, Alfred L., Pauli, Guido F., Suh, Joo-Won, Franzblau, Scott G., Cho, Sanghyun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4335914/
https://ncbi.nlm.nih.gov/pubmed/25421483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04054-14
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