Discovery and Characterization of the Tuberculosis Drug Lead Ecumicin

The new tuberculosis (TB) lead ecumicin (1), a cyclic tridecapeptide, was isolated from Nonomuraea sp. MJM5123, following a high-throughput campaign for anti-TB activity. The large molecular weight of 1599 amu detected by LC-HR-MS precluded the initial inference of its molecular formula. The individ...

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Bibliografske podrobnosti
izdano v:Org Lett
Main Authors: Gao, Wei, Kim, Jin-Yong, Chen, Shao-Nong, Cho, Sang-Hyun, Choi, Jongkeun, Jaki, Birgit U., Jin, Ying-Yu, Lankin, David C., Lee, Ji-Ean, Lee, Sun-Young, McAlpine, James B., Napolitano, José G., Franzblau, Scott G., Suh, Joo-Won, Pauli, Guido F.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5450905/
https://ncbi.nlm.nih.gov/pubmed/25409285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol5026603
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