The antibiotic cyclomarin blocks arginine-phosphate–induced millisecond dynamics in the N-terminal domain of ClpC1 from Mycobacterium tuberculosis

Mycobacterium tuberculosis can remain dormant in the host, an ability that explains the failure of many current tuberculosis treatments. Recently, the natural products cyclomarin, ecumicin, and lassomycin have been shown to efficiently kill Mycobacterium tuberculosis persisters. Their target is the...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Weinhäupl, Katharina, Brennich, Martha, Kazmaier, Uli, Lelievre, Joel, Ballell, Lluis, Goldberg, Alfred, Schanda, Paul, Fraga, Hugo
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Molecular Bases of Disease
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986217/
https://ncbi.nlm.nih.gov/pubmed/29632076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002251
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