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The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression
Helicase-like transcription factor (HLTF) is a central mediator of the DNA damage response and maintains genome stability by regressing stalled replication forks. The N-terminal HIRAN domain binds specifically to the 3′-end of single-stranded DNA (ssDNA), and disrupting this function interferes with...
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5986216/ https://ncbi.nlm.nih.gov/pubmed/29643183 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002905 |
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