Synthetic RNA-Based Immunomodulatory Gene Circuits for Cancer Immunotherapy

Despite its success in several clinical trials, cancer immunotherapy remains limited by the rarity of targetable tumor-specific antigens, tumor-mediated immune suppression, and toxicity triggered by systemic delivery of potent immunomodulators. Here, we present a proof-of-concept immunomodulatory ge...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Nissim, Lior, Wu, Ming-Ru, Pery, Erez, Binder-Nissim, Adina, Suzuki, Hiroshi I., Stupp, Doron, Wehrspaun, Claudia, Tabach, Yuval, Sharp, Phillip A., Lu, Timothy K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5986174/
https://ncbi.nlm.nih.gov/pubmed/29056342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2017.09.049
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