A high-throughput screening and computation platform for identifying synthetic promoters with enhanced cell-state specificity (SPECS)

Cell state-specific promoters constitute essential tools for basic research and biotechnology because they activate gene expression only under certain biological conditions. Synthetic Promoters with Enhanced Cell-State Specificity (SPECS) can be superior to native ones, but the design of such promot...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Wu, Ming-Ru, Nissim, Lior, Stupp, Doron, Pery, Erez, Binder-Nissim, Adina, Weisinger, Karen, Enghuus, Casper, Palacios, Sebastian R., Humphrey, Melissa, Zhang, Zhizhuo, Maria Novoa, Eva, Kellis, Manolis, Weiss, Ron, Rabkin, Samuel D., Tabach, Yuval, Lu, Timothy K.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599391/
https://ncbi.nlm.nih.gov/pubmed/31253799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10912-8
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