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Incoherent dose-escalation in phase I trials using the escalation with overdose control approach
A desirable property of any dose-escalation strategy for phase I oncology trials is coherence: if the previous patient experienced a toxicity, a higher dose is not recommended for the next patient; similarly, if the previous patient did not experience a toxicity, a lower dose is not recommended for...
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| Publicado no: | Stat Pap (Berl) |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5985932/ https://ncbi.nlm.nih.gov/pubmed/29875549 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00362-016-0790-7 |
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