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Toxicity‐dependent feasibility bounds for the escalation with overdose control approach in phase I cancer trials
Phase I trials of anti‐cancer therapies aim to identify a maximum tolerated dose (MTD), defined as the dose that causes unacceptable toxicity in a target proportion of patients. Both rule‐based and model‐based methods have been proposed for MTD recommendation. The escalation with overdose control (E...
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| Publicado no: | Stat Med |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5462100/ https://ncbi.nlm.nih.gov/pubmed/28295513 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.7280 |
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