The unfolded protein response: a novel therapeutic target for poor prognostic BRAF mutant colorectal cancer

BRAF(V600E) mutations occur in ~10% of colorectal cancer (CRC) cases, are associated with poor survival and have limited responses to BRAF/MEK inhibition with or without EGFR inhibition. There is an unmet need to understand the biology of poor prognostic BRAFMT CRC. We have used differential gene ex...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Forsythe, Nicholas, Refaat, Alaa, Javadi, Arman, Khawaja, Hajrah, Weir, Jessica-Anne, Emam, Heba, Allen, Wendy L., Burkamp, Frank, Popovici, Vlad, Jithesh, Puthen V., Isella, Claudio, Labonte, Melissa J., Mills, Ian G., Johnston, Patrick G., Van Schaeybroeck, Sandra
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985931/
https://ncbi.nlm.nih.gov/pubmed/29483217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0603
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