Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons

The nuclear-encoded glycyl-tRNA synthetase gene (GARS) is essential for protein translation in both cytoplasm and mitochondria. In contrast, different genes encode the mitochondrial and cytosolic forms of most other tRNA synthetases. Dominant GARS mutations were described in inherited neuropathies,...

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Publicat a:Hum Mol Genet
Autors principals: Boczonadi, Veronika, Meyer, Kathrin, Gonczarowska-Jorge, Humberto, Griffin, Helen, Roos, Andreas, Bartsakoulia, Marina, Bansagi, Boglarka, Ricci, Giulia, Palinkas, Fanni, Zahedi, René P, Bruni, Francesco, Kaspar, Brian, Lochmüller, Hanns, Boycott, Kym M, Müller, Juliane S, Horvath, Rita
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985729/
https://ncbi.nlm.nih.gov/pubmed/29648643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy127
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