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Mutations in glycyl-tRNA synthetase impair mitochondrial metabolism in neurons
The nuclear-encoded glycyl-tRNA synthetase gene (GARS) is essential for protein translation in both cytoplasm and mitochondria. In contrast, different genes encode the mitochondrial and cytosolic forms of most other tRNA synthetases. Dominant GARS mutations were described in inherited neuropathies,...
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| Published in: | Hum Mol Genet |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2018
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5985729/ https://ncbi.nlm.nih.gov/pubmed/29648643 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy127 |
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