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Aging genomes: A necessary evil in the logic of life

Genomes are inherently unstable because of the need for DNA sequence variation as a substrate for evolution through natural selection. However, most multicellular organisms have postmitotic tissues, with limited opportunity for selective removal of cells harboring persistent damage and deleterious m...

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Bibliografiske detaljer
Udgivet i:Bioessays
Hovedforfatter: Vijg, Jan
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985526/
https://ncbi.nlm.nih.gov/pubmed/24464418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bies.201300127
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