Intravenous adenovirus expressing a multi-specific, single-domain antibody neutralizing TcdA and TcdB protects mice from Clostridium difficile infection

Clostridium difficile infection (CDI) is the most common cause of antibiotic-associated diarrhea and colitis in developed countries. The disease is mainly mediated via two major exotoxins TcdA and TcdB secreted by the bacterium. We have previously developed a novel, potently neutralizing, tetravalen...

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Bibliographische Detailangaben
Veröffentlicht in:Pathog Dis
Hauptverfasser: Yang, Zhiyong, Shi, Lianfa, Yu, Hua, Zhang, Yongrong, Chen, Kevin, Saint Fleur, Ashley, Bai, Guang, Feng, Hanping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985491/
https://ncbi.nlm.nih.gov/pubmed/27502696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/femspd/ftw078
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