Modeling human pancreatic beta cell dedifferentiation

OBJECTIVE: Dedifferentiation could explain reduced functional pancreatic β-cell mass in type 2 diabetes (T2D). METHODS: Here we model human β-cell dedifferentiation using growth factor stimulation in the human β-cell line, EndoC-βH1, and human pancreatic islets. RESULTS: Fibroblast growth factor 2 (...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Diedisheim, Marc, Oshima, Masaya, Albagli, Olivier, Huldt, Charlotte Wennberg, Ahlstedt, Ingela, Clausen, Maryam, Menon, Suraj, Aivazidis, Alexander, Andreasson, Anne-Christine, Haynes, William G., Marchetti, Piero, Marselli, Lorella, Armanet, Mathieu, Chimienti, Fabrice, Scharfmann, Raphael
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985229/
https://ncbi.nlm.nih.gov/pubmed/29472102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2018.02.002
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