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Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis
Phlpp protein phosphatases are abnormally abundant within human osteoarthritic articular chondrocytes and may contribute to the development of osteoarthritis. Mice lacking Phlpp1 were previously shown to be resistant to post-traumatic osteoarthritis. Here a small molecule with therapeutic properties...
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| Publicado no: | J Orthop Res |
|---|---|
| Main Authors: | , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5985222/ https://ncbi.nlm.nih.gov/pubmed/29068480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.23781 |
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