Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis

OBJECTIVE: Recent reports have implicated the p53 tumor suppressor in the regulation of lipid metabolism. We hypothesized that the pharmacological activation of p53 with low-dose doxorubicin, which is widely used to treat several types of cancer, may have beneficial effects on nonalcoholic fatty liv...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Porteiro, Begoña, Fondevila, Marcos F., Buque, Xabier, Gonzalez-Rellan, Maria J., Fernandez, Uxia, Mora, Alfonso, Beiroa, Daniel, Senra, Ana, Gallego, Rosalia, Fernø, Johan, López, Miguel, Sabio, Guadalupe, Dieguez, Carlos, Aspichueta, Patricia, Nogueiras, Rubén
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5985045/
https://ncbi.nlm.nih.gov/pubmed/29290620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.12.005
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