Hepatic p63 regulates steatosis via IKKβ/ER stress

p53 family members control several metabolic and cellular functions. The p53 ortholog p63 modulates cellular adaptations to stress and has a major role in cell maintenance and proliferation. Here we show that p63 regulates hepatic lipid metabolism. Mice with liver-specific p53 deletion develop steat...

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Pubblicato in:Nat Commun
Autori principali: Porteiro, Begoña, Fondevila, Marcos F., Delgado, Teresa C., Iglesias, Cristina, Imbernon, Monica, Iruzubieta, Paula, Crespo, Javier, Zabala-Letona, Amaia, Fernø, Johan, González-Terán, Bárbara, Matesanz, Nuria, Hernández-Cosido, Lourdes, Marcos, Miguel, Tovar, Sulay, Vidal, Anxo, Sánchez-Ceinos, Julia, Malagon, Maria M., Pombo, Celia, Zalvide, Juan, Carracedo, Arkaitz, Buque, Xabier, Dieguez, Carlos, Sabio, Guadalupe, López, Miguel, Aspichueta, Patricia, Martínez-Chantar, María L., Nogueiras, Ruben
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5424198/
https://ncbi.nlm.nih.gov/pubmed/28480888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15111
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